Farrukh Awan, MD, MS John C. Byrd, MD

Staging and Prognostic Factors in CLL

Thus far, no study has shown a survival advantage with early treatment in patients with CLL and a subset of CLL patients will never require therapy. This has led to the research efforts in CLL that have identified several specific biologic or clinical prognostic factors that predict time to progression and overall survival. With these recent...

	Constantine S. Tam, MB, BS Susan Lerner, MS Michael J. Keating, MB, BS

New Prognostic Markers in CLL

The recent proliferation of new "prognostic markers" in chronic lymphocytic leukemia (CLL) has provided valuable insights into the biology of the disease.¹ In particular, significant survival differences when patients are classified by immunoglobulin heavy chain variable region (IGVH) mutation status^2,3, fluorescent in-situ hybridization (FISH)...