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The role of prognostic factors in assessing 'high-risk' subgroups of patients with chronic lymphocytic leukemia
Source: Leukemia Hematology - June 14, 2007

The management of chronic lymphocytic leukemia (CLL) has historically relied on 'watchful waiting' and palliative approaches to therapy. However, the course of disease is highly variable and a substantial proportion of patients with early-stage CLL develop rapidly progressive disease requiring therapy. In recent decades, numerous clinical and biological prognostic markers that are predictive of decreased survival outcomes, disease progression and/or resistance to therapy, and that may play a role in defining the subgroups of patients with 'high-risk' CLL have been identified. At the same time, highly effective treatment modalities have become available with the advent of chemoimmunotherapy combinations and allogeneic stem cell transplantation. Thus, we are approaching an era when patients with CLL may potentially benefit from individualized risk assessments based on prognostic markers and when specific therapies may be offered to the subgroup of patients with high-risk disease. This review provides a brief overview of newer biological prognostic markers, discusses the challenges associated with identifying the subgroup of patients with high-risk CLL and further aims to provide recommendations on how prognostic markers may be used to assess high-risk subgroups in different clinical situations in CLL.

Click on the links below to view news articles on Chronic Lymphocytic Leukemia from the past six months.

CLL News & Commentary - provided by Medworm

Researchers tackle cll, diabetes and trauma-hemorrhage - molecular medicine, a bi-monthly journal

Source: Lymphoma / Leukemia News From Medical News Today - Tuesday, November 18, 2008

Cv technologies inc.: world's top cancer research body sponsors landmark cold-fx(r) trial

Source: Market Wire - Pharmaceuticals and Biotech - Monday, November 17, 2008

Vaccination history and risk of non-hodgkin lymphoma: a population-based, case–control study

Source: Cancer Causes and Control - Sunday, November 16, 2008

Researchers tackle cll, diabetes and trauma-hemorrhage

Source: PRWeb: Medical Pharmaceuticals - Friday, November 14, 2008

Chronic lymphocytic leukemia (cll) cells genetically modified to express b7-1, icam-1, and lfa-3 confer apc capacity to t cells from cll patients

Source: Cancer Immunology, Immunotherapy - Thursday, November 13, 2008

Coexistent chronic lymphocytic leukemia and polycythemia vera requiring no treatment

Source: Medical Oncology - Thursday, November 13, 2008

Studies on monoclonal anti-isotypic and anti-idiotypic antibodies against leukemia and myeloma: i. preparation and characteristics of monoclonal anti-isotypic antibodies to igm from b chronic lymphocytic leukemia

Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - Thursday, November 13, 2008

Caspase-independent type iii pcd: a new means to modulate cell death in chronic lymphocytic leukemia

Source: Leukemia - Wednesday, November 12, 2008

Genmab a/s: ofatumumab pivotal cll data to be presented at ash

Source: Lymphoma / Leukemia News From Medical News Today - Monday, November 10, 2008

Pharmacokinetics of alemtuzumab in combination with fludarabine in patients with relapsed or refractory b-cell chronic lymphocytic leukemia.

Source: Haematologica - Sunday, November 09, 2008

[first-line therapy of chronic lymphocytic leukemia in the elderly: be careful with overtreatment.]

Source: Presse Medicale - Sunday, November 09, 2008

Case report and literature review: a rare patient with chronic myeloid leukemia and chronic lymphocytic leukemia.

Source: Annals of Clinical and Laboratory Science - Saturday, November 08, 2008

Fcrl6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with b-cell chronic lymphocytic leukemia.

Source: European Journal of Immunology - Thursday, November 06, 2008

Overexpression of toso in cll is triggered by b-cell receptor signaling and associated with progressive disease

Source: Blood - Wednesday, November 05, 2008

A prospective study of mitochondrial dna copy number and risk of non-hodgkin lymphoma

Source: Blood - Wednesday, November 05, 2008

[diagnosis in oncology] chronic lymphocytic leukemia with eyelid involvement responding to alemtuzumab

Source: Journal of Clinical Oncology - Wednesday, November 05, 2008

Treatment of b-cell chronic lymphocytic leukemia with nonchemotherapeutic agents: experience with single-agent and combination therapy

Source: Leukemia - Wednesday, November 05, 2008

Correspondence: monoclonal b-cell lymphocytosis and chronic lymphocytic leukemia

Source: New England Journal of Medicine - Tuesday, November 04, 2008

Novel leukemia vaccine for high-risk patients studied at moores ucsd cancer center

Source: Genetics News From Medical News Today - Tuesday, November 04, 2008

Small lymphocytic lymphoma/chronic lymphocytic leukemia in a pelvic myelolipoma.

Source: International Journal of Clinical and Experimental Pathology - Sunday, November 02, 2008

Pitfalls in diagnostic hematopathology: part i.

Source: International Journal of Clinical and Experimental Pathology - Sunday, November 02, 2008

Bendamustine is effective in p53-deficient b-cell neoplasms and requires oxidative stress and caspase-independent signaling.

Source: Clinical Cancer Research - Friday, October 31, 2008

Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation.

Source: Molecular Medicine - Friday, October 31, 2008

Ionizing radiation and risk of chronic lymphocytic leukemia in the 15-country study of nuclear industry workers.

Source: Radiation Research - Friday, October 31, 2008

[leukemia and bone marrow transplantation] allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: a retrospective european group for blood and marrow transplantation analysis

Source: Journal of Clinical Oncology - Wednesday, October 29, 2008

Gemin x pan bcl-2 inhibitor obatoclax shows biological, clinical activity in heavily pre-treated patients with advanced chronic lymphocytic leukemia

Source: Lymphoma / Leukemia News From Medical News Today - Wednesday, October 29, 2008

The effect of in vivo t cell depletion with alemtuzumab on reduced-intensity allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia.

Source: Biology of Blood and Marrow Transplantation - Friday, October 24, 2008

Il-24 induces apoptosis of chronic lymphocytic leukemia b cells engaged into the cell cycle through dephosphorylation of stat3 and stabilization of p53 expression.

Source: Journal of Immunology - Friday, October 24, 2008

P2x7 gene polymorphisms do not appear to be a susceptibility gene locus in sporadic cases of systemic lupus erythematosus.

Source: Tissue Antigens - Thursday, October 23, 2008

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

Source: Blood - Wednesday, October 22, 2008

P53-mediated apoptosis of cll cells: evidence for a transcription-independent mechanism

Source: Blood - Wednesday, October 22, 2008

Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib

Source: Blood - Wednesday, October 22, 2008

Leukemia drug may benefit multiple sclerosis patients

Source: MedPage Today Neurology - Wednesday, October 22, 2008

Identification of tigar in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells.

Source: Haematologica - Tuesday, October 21, 2008